Why We Switched from Immunoassays to LC-MS/MS for Measuring Salivary and Blood (DBS) Hormones 

Presenter: Dr. David Zava

Join our founder, Dr. David Zava, for an in-depth look at ZRT’s transition from conventional immunoassays to liquid chromatography–tandem mass spectrometry (LC-MS/MS) for measuring steroid hormones in saliva and dried blood spot (DBS) samples.

Specific topics addressed include:

• Explanation of the technical differences between immunoassays and LC-MS/MS
• Why immunoassays may be less accurate for measuring steroid hormones, particularly at low concentrations such as estradiol and testosterone in postmenopausal women
• How certain high-dose exogenous hormone therapies (e.g., estriol, oral progesterone) can lead to false-high results when using immunoassays, but not LC-MS/MS

💡 Live Q&A: Dr. Zava concludes with a dedicated Q&A session to answer questions and discuss clinical application.

Related Resources

• Learn More: Testing Upgrade Overview & FAQs
• Handout: Panel Transition Guide
• Handout: Overview of Kits