ZRT has tested over 150,000 men experiencing hormone decline.

Men at mid-life are just as susceptible to an age-related drop in hormone production as their female counterparts. Andropause, the so-called male menopause, signifies the retreat of the key male hormone testosterone.

As a man ages, his body naturally makes less testosterone. In fact, by the time a man is in his mid-forties, testosterone levels can be down by 40%. Lifestyle factors such as excessive stress, weight gain and lack of exercise can lower levels even further – impacting stamina, drive and virility.

Men tend to notice a subtle downward shift in strength and energy first, followed by lack of enthusiasm for life’s challenges like work and competition. A man may also lose interest in sex. The hidden imbalances contributing to these factors generally include:

Low Testosterone

Leads to decreased stamina and libido, fatigue & erectile dysfunction

High Estrogen

Results in weight gain, increased chest and belly fat, hot flashes, night sweats & excessive need to urinate (BPH)

High Cortisol

Results in insomnia, anxiety, sugar cravings, feeling tired but wired & increased belly fat

Low Cortisol

Causes chronic fatigue, low energy, food and sugar cravings, poor exercise tolerance or recovery & low immune reserves

Thyroid Imbalance

This condition is commonly missed in men and may often mimic symptoms of low testosterone.

CardioMetabolic Issues

This includes high blood pressure and diabetes, and may mimic some symptoms of low testosterone – like fatigue or erectile dysfunction.

High DHT

Results in excessive need to urinate (BPH), hair loss, acne

Learn More About Andropause

Webinar: Navigating Changes in the Aging Male

Blog: Andropause – Real Men Go For Balance

Blog: SHBG – A Modulator to be Modulated

Andropause Testing Options

To restore the vital balance of hormones, we first need a detailed, accurate measurement of hormone levels. Not just numbers, but an assessment that offers real meaning.

Confused about when to test in saliva, blood, and urine? Click here to learn more.


ZRT Laboratory Saliva Hormone Test Kit

Saliva Test Kit Includes:

Saliva Profile I – E2, Pg, T, DS & Cx1

Saliva Profile II – E2, Pg, T, DS & Cx2

Saliva Profile III – E2, Pg, T, DS & Cx4 (Sample Report)

Hormone Trio – E2, Pg & T

LCMS Saliva Steroid Profile – E2, E3, E1, EE, PregS, Pg, AlloP, 17OHPg, Adione, T, DHT, D, DS, 7keto, 11DC, C, Cn, Ccn, Ald, Mel, ANZ, FIN & LTZ (Sample Report)


ZRT Laboratory Saliva + Blood Hormone Test Kit

Saliva + Blood Spot Test Kit Includes:

Male Comprehensive Profile I – E2, T, DS & Cx4 (saliva); PSA, TSH, fT3, fT4 & TPOab (blood spot) (Sample Report)

Male Comprehensive Profile II – Cx4 (saliva); E2, T, DS, SHBG, PSA, TSH, fT3, fT4 & TPOab (blood spot) (Sample Report)


ZRT Laboratory Blood Spot Hormone Test Kit

Blood Spot Test Kit Includes:

Male Blood Profile I – E2, T, DS, C, SHBG & PSA

Male Blood Profile II – E2, T, DS, C, SHBG, PSA, TSH, fT3, fT4 & TPOab

Essential Thyroid Profile – fT3, fT4, TPOab & TSH

Elite Thyroid Profile - T4, Tgbn, fT4, fT3, TPO & TSH

CardioMetabolic Profile – Insulin, hsCRP, HbA1c, TG, CH, LDL, HDL & VLDL (Sample Report)


ZRT Laboratory Serum Kit

Serum Test Kit Includes:

Female Serum Hormones - Basic: E2, Pg, T, DS, C, SHBG & TSH 

Male Serum Hormones - Basic:  E2, T, DS, C, SHBG, PSA & TSH

Female Serum Hormones - Advanced: E2, Pg, T, DS, C, SHBG, TSH, fT3, fT4, TPOab, FSH, LH & FER (Sample Report)

Male Serum Hormones - Advanced: E2, T, DS, C, SHBG, PSA, TSH, fT3, fT4, TPOab, LH, PRL & FER

Methylation: FER, FOL, HCY & B12

Methylation and Memory - Basic: E2, Pg, T, SHBG, TSH, FOL, B12, HCY

Methylation and Memory - Advanced: E2, Pg, T, DS, C, SHBG, TSH, fT3, fT4, TPOab, FER, FOL, B12, HCY


ZRT Laboratory Urine Metabolites Kit

Urine Metabolites Test Kit Includes:

Advanced Metabolites Profile – Our broadest view of sex steroid hormone metabolite levels and cortisol metabolism with full diurnal melatonin and BPA. 44 tests. (Sample Report)

View Metabolites Tests Included in Advanced Metabolites Profile


ZRT Laboratory Neurotransmitters Kit

Neurotransmitter Test Kit Includes:

NeuroAdvanced Profile – GABA, Glu, Gly, DA, Epi, NE, HIST, 5-HT, PEA, DOPAC, HVA, 5-HIAA, NMN, VMA & Crtn (Sample Report)

Saliva Hormones add-on – E2, Pg, T, DS & C

Urine Hormones add-on – E2, Pregnanediol, Allopregnanolone, Androstenedione, T, Epi-T, DHT, DHEA, & 5α,3α-Androstanediol

Diurnal Cortisol add-on – Free Cortisol x 4 & Free Cortisone x 4

Diurnal Cortisol & Melatonin add-on – Free Cortisol x 4, Free Cortisone x 4 & Melatonin (MT6s) x 4

Diurnal Cortisol, Norepinephrine & Epinephrine add-on – Free Cortisol x 4, Free Cortisone x 4, NE x 4 & Epi x 4

Diurnal Cortisol, Melatonin, Norepinephrine & Epinephrine add-on – Free Cortisol x 4, Free Cortisone x 4, Melatonin (MT6s) x 4, NE x 4 & Epi x 4

Urine Toxic & Essential Elements add-on – I, Se, Br, Li, As, Cd & Hg


Reference Information

Testing Catalog

Overview of Kits

ZRT Test Directory & Abbreviations

Saliva Reference Ranges

LCMS Saliva Steroid Reference Ranges

Dried Blood Spot Reference Ranges

LCMS Dried Blood Spot Reference Ranges

Serum Reference Ranges

Urine Hormone Metabolites Reference Ranges

Neurotransmitter Reference Ranges


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