60 million suffer symptoms of insomnia. Find out whether hormones contribute to your sleep loss.

In a perfect world, the master stress hormone cortisol should be in sync with the master sleep hormone melatonin. Each hormone counter-balances the other in a precise rhythm – when cortisol is high melatonin should be low, and when melatonin is high cortisol should be low.

For many, this rhythm is out of balance. With an estimated 60 million Americans suffering from some degree of sleep loss, it’s surprising that many are still unaware of the connection between hormones and sleep.

See how diurnal curves of cortisol and melatonin affect sleep and how diurnal epinephrine and norepinephrine aid in assessing the stress response affecting sleep.

The Downside of Chronic Sleep Loss

According to the Department of Health & Human Services, over a third of U.S. adults report daytime sleepiness so severe it interferes with work, decision making and social functioning.

In fact, depression, obesity and diabetes are just three of the long term consequences of sleep deprivation – defined as six or fewer hours per night.

Common hormone-related causes of sleep loss often involve the following scenarios:

High Cortisol

Results in insomnia, anxiety, sugar cravings, feeling tired but wired & increased belly fat

Low Melatonin

Results in excessive fatigue, depression, anxiety & insomnia

Neurotransmitter Imbalance

Changes in sex steroid hormone levels during menopause can impact neurotransmitter levels, leading to recurring sleep issues.

Learn More About Sleep Balance


Recommended for Practitioners:

Webinar: Hormones & Sleep Disturbances

Datasheet: Sleep Balance Profile


Recommended for Patients:

Webinar: The Truth About Sleepless Nights

Blog: The Role of Hormones in Sleep Disturbances

Sleep Balance Testing Options

To restore the vital balance of hormones, we first need a detailed, accurate measurement of hormone levels. Not just numbers, but an assessment that offers real meaning.


ZRT Laboratory Sleep Balance Kit

Sleep Balance Test Kit Includes:

Sleep Balance Profile – Cortisol x 4, Cortisone x 4, Melatonin (MT6s) x 4 & Crtn (Sample Report)

Norepinephrine & Epinephrine add-on – NE x 4 & Epi x 4


ZRT Laboratory Neurotransmitters Kit

Neurotransmitters Test Kit Includes:

NeuroAdvanced Profile – GABA, Glu, Gly, DA, Epi, NE, HIST, 5-HT, PEA, DOPAC, HVA, 5-HIAA, NMN, VMA & Crtn (Sample Report)

Saliva Hormones add-on – E2, Pg, T, DS & C

Urine Hormones add-on – E2, Pregnanediol, Allopregnanolone, Androstenedione, T, Epi-T, DHT, DHEA, & 5α,3α-Androstanediol

Diurnal Cortisol add-on – Free Cortisol x 4 & Free Cortisone x 4

Diurnal Cortisol & Melatonin add-on – Free Cortisol x 4, Free Cortisone x 4 & Melatonin (MT6s) x 4

Diurnal Cortisol, Norepinephrine & Epinephrine add-on – Free Cortisol x 4, Free Cortisone x 4, NE x 4 & Epi x 4

Diurnal Cortisol, Melatonin, Norepinephrine & Epinephrine add-on – Free Cortisol x 4, Free Cortisone x 4, Melatonin (MT6s) x 4, NE x 4 & Epi x 4

Urine Toxic & Essential Elements add-on – I, Se, Br, Li, As, Cd & Hg


ZRT Laboratory Adrenal Stress Kit

Adrenal Stress Test Kit Includes:

Adrenal Stress Profile – DS & Cx4 (Sample Report)


ZRT Laboratory Urine Metabolites Kit

Urine Metabolites Test Kit Includes:

Adrenal Profile – A picture of adrenal hormone metabolism. 13 tests.

Advanced Metabolites Profile – Our broadest view of sex steroid hormone metabolite levels and cortisol metabolism with full diurnal melatonin and BPA. 44 tests. (Sample Report)

View Metabolites Tests Included in Each Profile


ZRT Laboratory Cortisol Awakening Response Kit

Cortisol Awakening Response Test Kit Includes:

Cortisol Awakening Response Profile (CAR) – DS & Cx6 (Sample Report)


Reference Information

Testing Catalog

Overview of Kits

ZRT Test Directory & Abbreviations

Neurotransmitter Reference Ranges

Urine Hormone Metabolites Reference Ranges


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