SHBG, or Sex Hormone Binding Globulin, controls testosterone effect in both men and women by modulating changes in sex steroid levels. When SHBG goes up, free testosterone goes down. I like to think of SHBG as a sponge that soaks up androgens and to some degree estrogens as well. Since it binds so specifically and tightly to testosterone, it makes up part of the equation that equals androgen excess…

Tags: Hormone Balance, Testosterone, Andropause, SHBG

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SHBG – A Modulator to be Modulated

The testicles of a man in his 20s are known to contribute about 5-10mg of testosterone per 24-hour day and levels of total testosterone in the venous blood with that amount are observed to yield roughly 300-1200 ng/dL in the morning at the diurnal peak. Testosterone, whether endogenous or given exogenously, negatively feeds back on the hypothalamus, limiting GnRH and thus LH and FSH from the…

Tags: Testosterone, BHRT, Hormone Balance

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Topical Testosterone & the U-Shaped Curve

Men and testosterone therapy have been a hot topic in the news recently. Stories are filled with cautions about the use of testosterone therapy in men causing heart attacks and leading many doctors to question testosterone supplementation. A closer look at the study may provide more insight. The study released is referenced at the end of this post. This study looked at 55,593 men who started…

Tags: Heart Health, Testosterone, Hormone Balance, Cardiovascular Disease, Andropause

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Men's Heart Health & Testosterone

An FDA-approved testosterone gel was shown to significantly increase risk for adverse cardiovascular, respiratory, and dermatological events in men 65 or older who had impaired mobility and increased health risks. This is according to a recent study published in the prestigious New England Journal of Medicine (NEJM) that casts a shadow on the common use of testosterone therapy in older men for…

Tags: Saliva Testing, Blood Spot Testing, Testosterone, BHRT, Hormone Balance

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Testosterone: Elixir or Dangerous Drug?

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